| 10-17 | Injury | Guus Til — Guus Til suffered a head injury and was substituted in the first half against ADO Den Haag. |
| 10-17 | Suspension | Sven Mijnans — Sven Mijnans received a red card against ADO Den Haag resulting in a suspension. |
| 09-25 | Injury | Lutsharel Geertruida — Lutsharel Geertruida withdrew from international duty and returned to PSV Eindhoven after suffering a minor injury. |
| 09-22 | Injury | Ricardo Pepi — Ricardo Pepi suffered an injury and will miss upcoming matches for PSV Eindhoven. |
| 09-20 | Injury | Ricardo Pepi — Ricardo Pepi suffered an injury during PSV's match against FC Twente and was withdrawn from international duty. |
| 09-04 | Transfer in | Mikkel Bro Hansen — PSV signed Danish forward Mikkel Bro Hansen from Bodo/Glimt on a three-year contract. |
| 09-02 | Transfer in | Sam Lammers — Sam Lammers completes a permanent transfer to PSV Eindhoven from Twente. |
| 09-02 | Transfer out | Joel van den Berg — Joel van den Berg signs for Celtic from PSV Eindhoven. |
| 09-02 | Contract | Amir Bouhamdi — Amir Bouhamdi signs a contract extension with PSV Eindhoven until 2031. |
| 09-01 | Transfer in | Sami Ouaissa — PSV Eindhoven signed winger Sami Ouaissa from Nijmegen. |
| 08-25 | Transfer out | Couhaib Driouech — Couhaib Driouech completes a permanent transfer to Celta de Vigo. |
| 08-21 | Transfer in | Lutsharel Geertruida — PSV Eindhoven signed Lutsharel Geertruida on loan from RB Leipzig with an option to make the move permanent. |